AEG 618K 8 Manual de usuario descargar pdf (Pagina 3)

Inhaltsverzeichnis

1 Einleitung ........................................................................................................... 5

1.1 Die humanen Immundefizienzviren ..................................................................................... 5

1.1.1 Vorkommen und Verbreitung von HIV .......................................................................... 5

1.1.2 Diversität von HIV ......................................................................................................... 6

1.1.3 Transmission von HIV ................................................................................................... 6

1.1.4 Maßnahmen zur Reduktion der vertikalen Transmission von HIV ............................... 7

1.2 Antiretrovirale Medikamente gegen HIV ............................................................................ 8

1.2.1 Antiretrovirale Therapie .................................................................................................. 9

1.2.2 Antiretrovirale Prophylaxeregime für die vertikale HIV-Transmission ....................... 9

1.3 HIV-Resistenzen gegen antiretovirale Medikamente ....................................................... 12

1.3.1 Entstehung von Resistenzen .......................................................................................... 13

1.3.2 Übertragung und Persistenz von Resistenzen ................................................................ 15

1.3.3 Methoden der Resistenzbestimmung ............................................................................. 16

2Zielsetzung ....................................................................................................... 18

3Ergebnisse ........................................................................................................ 20

3.1 Liste aller Einzelarbeiten ..................................................................................................... 20

3.2 Eigenanteil an den Einzelarbeiten ...................................................................................... 21

3.3 Manuskript I - Abstract ....................................................................................................... 22

Detection and quantification of minor human immunodeficiency virus type 1

variants harboring K103N and Y181C resistance mutations in subtype A and D

isolates by allele-specific real-time PCR.

3.4 Manuskript II - Abstract ..................................................................................................... 23

Emergence and persistence of minor drug-resistant HIV-1 variants in Ugandan

women after nevirapine single-dose prophylaxis.

3.5 Manuskript III - Abstract .................................................................................................... 24

Dynamics of NVP-resistance development in HIV of Ugandan mother-child pairs

during 18 months after nevirapine single-dose exposure to reduce vertical

transmission.

3.6 Manuskript IV - Abstract .................................................................................................... 25

Minor drug-resistant HIV type-1 variants in breast milk and plasma of HIV type-1-

infected Ugandan women after nevirapine single-dose prophylaxis.

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AEG 618K 8 Manual de usuario Pagina 3